New Method of Vaccination Against Anthrax

The aim of this work was to develop an oral method vaccination against anthrax, since wide campaigns using require no special conditions, equipment, and instruments. Also, minimum number medical personnel is sufficient ensure control over the intake drug. Materials methods. Domestic raw materials, consumables reagents that passed incoming inspection met requirements State industry standards, technical specifications, articles Pharmacopoeia were used for work. Batches anthrax vaccines based on Bacillus anthracis strain STI-1, manufactured at Research Center (Kirov) “48th Central Institute” Ministry Defense Russia put test. Results discussion. immunization schemes have been tested animals, taking into account features antigen. One crucial factors determine effectiveness correct choice type form vaccine administered enterally. It has shown in contrast vaccines, enteral must be protected from harmful effects stomach contents. Thus, enteric-coated capsules coated with a shell resistant action acid study. presented experimental data indicate single administration STI protects least 70 % laboratory animals highly virulent microbe confirm safety non-reactogenicity developed technology makes it possible obtain finished product containing one inoculation dose animals. So, new designed. necessary conduct preclinical clinical trials promptly introduce practice as simplest mass humans.